Course Overview

This course explores the neurobiological foundations of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, through an evidence-based lens. By examining cutting-edge research, students will gain a deeper understanding of cognitive decline, neuroplasticity, and emerging interventions aimed at promoting cognitive resilience. The course also covers ethical and regulatory considerations in clinical research, equipping students with critical knowledge for navigating the field of cognitive health.

Learning Objectives
By the end of this course, students will be able to:

• Examine the neurobiological mechanisms underlying neurodegenerative diseases, including Alzheimer’s and Parkinson’s.
• Review academic research on neuroplasticity and cognitive function in relation to novel interventions.
• Discuss ethical, regulatory, and safety considerations in research on alternative approaches to cognitive health.

Course Outline

Understanding Neurodegenerative Diseases

• Overview of Alzheimer’s disease, Parkinson’s disease, and related neurodegenerative conditions.
• The role of beta-amyloid plaques, tau proteins, and dopaminergic neuron loss in disease progression.
• Current treatment approaches, including cholinesterase inhibitors, dopamine replacement therapy, and neuroprotective strategies.

Neurobiological Mechanisms of Cognitive Decline & Neuroplasticity

• The impact of aging, oxidative stress, and neuroinflammation on brain function.
• Mechanisms of synaptogenesis, neuronal regeneration, and brain connectivity enhancement.
• Role of serotonin receptors and neurotrophic factors (e.g., BDNF) in cognitive resilience.

Academic Research & Clinical Findings

• Review of studies exploring alternative interventions for neurodegenerative conditions.
• Madsen et al. (2020) – Investigation of novel approaches to synaptogenesis (Cell Reports).
• Discussion of findings, limitations, and future directions in cognitive health research.

Regulatory & Ethical Considerations

• Compliance with ethical guidelines in research on neurodegenerative diseases.
• Considerations for informed consent, safety protocols, and patient well-being in clinical studies.
• Future research directions and emerging therapeutic strategies.

Assessment
Students will complete a 10-question multiple-choice test assessing their understanding of neurodegeneration, research findings, and ethical considerations.

This course provides a comprehensive foundation in the latest scientific advancements, offering students valuable insights into the evolving landscape of neurodegenerative disease research.